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------=_NextPart_01C9C746.8C206060 Content-Location: file:///C:/21943233/slides-veins_files/master18.xml Content-Transfer-Encoding: quoted-printable Content-Type: text/xml; charset="utf-8" ------=_NextPart_01C9C746.8C206060 Content-Location: file:///C:/21943233/slides-veins_files/pres.xml Content-Transfer-Encoding: quoted-printable Content-Type: text/xml; charset="utf-8" ------=_NextPart_01C9C746.8C206060 Content-Location: file:///C:/21943233/slides-veins_files/slide0098.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" SABS I: Vascular Physiology
SABS I: Vascular Physiology
Steven J. Miller, Ph.D. =
Office: 274-2657
E-Mail: sjmiller@iupui.edu =
http://www.iuvascular.com/U= nthank/teach.html
VEINS & VENULES
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SABS I
Veins and Venules
2
IV. Ve= ins and Venules
<= span style=3D'mso-special-format:"numbullet1\,1";position:absolute;left:-7.9%; top:-.08em;font-size:110%'>A.Fundamental facts:  The venous system = ;
<= span style=3D'mso-special-format:"numbullet3\,1";color:yellow;position:absolute; left:-7.9%;top:-.08em;font-size:110%'>1. is a large blood reservoir (75% TBV)
2.assists in the return of blood to the heart  by venous pumps
<= span style=3D'mso-special-format:"numbullet3\,1";color:yellow;position:absolute; left:-6.82%;top:-.08em;font-size:110%'>3. is involv= ed in the regulation of cardiac output
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SABS I
Veins and Venules
3
IV. Ve= ins and Venules
•<= /span>B.  Venous Reservoir
<= span style=3D'mso-special-format:bullet;color:#99CCFF;mso-color-index:5;positio= n: absolute;left:-7.32%;top:-.08em;font-size:110%'>•Distribution of blood volume
•Most of the blood is in t= he venous system; primarily in small veins and venules
•Changes in venous tone al= ter venous volume and thereby influence the end diastolic volume of the heart and cardiac output (SV vs= . EDV; Frank-Starling law of heart)
------=_NextPart_01C9C746.8C206060 Content-Location: file:///C:/21943233/slides-veins_files/slide0117.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" SABS I: Vascular Physiology
test
Overview
4
Blood Volume Distribution
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SABS I
Veins and Venules
5
IV. Ve= ins and Venules
•<= /span>C.  Venous Pumps
<= span style=3D'mso-special-format:bullet;color:#99CCFF;mso-color-index:5;positio= n: absolute;left:-7.35%;top:-.08em;font-size:110%'>•Ventilation pump & Sk= eletal muscle pump
•Promote venous flow by altering venous pressures
<= span style=3D'mso-special-format:bullet;color:yellow;position:absolute;left:-6.= 93%; top:-.08em;font-size:110%'>•Efficient function requires presence of valves
------=_NextPart_01C9C746.8C206060 Content-Location: file:///C:/21943233/slides-veins_files/slide0118.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" SABS I: Vascular Physiology
test
Overview
6
Venous “Pumps”
<= ![if !vml]>=3D19-22 <= ![if !vml]>=3D15-22
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SABS I
Veins and Venules
7
IV. Ve= ins and Venules
•<= /span>D.  Venous Return and Cardiac Output&= #13;
<= span style=3D'mso-special-format:bullet;color:#99CCFF;mso-color-index:5;positio= n: absolute;left:-8.48%;top:-.08em;font-size:110%'>•VR =3D CO
<= span style=3D'mso-special-format:bullet;color:#99CCFF;mso-color-index:5;positio= n: absolute;left:-8.48%;top:-.08em;font-size:110%'>•VR=3DDP/R= =3D(MCFP-CVP)/RVR
<= span style=3D'font-family:"CG Times"'>R= 26;VR =3D Venous Return&#= 13;
<= span style=3D'font-family:"CG Times"'>R= 26;MCFP =3D Mean Circulat= ory Filling Pressure
<= span style=3D'mso-special-format:bullet;color:yellow;position:absolute;left:-7.= 56%; top:-.08em;font-size:110%'>•CVP =3D Central Venous Pressure
•<= /span> = ;
------=_NextPart_01C9C746.8C206060 Content-Location: file:///C:/21943233/slides-veins_files/slide0072.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" SABS I: Vascular Physiology
SABS I
Veins and Venules
8
IV. Ve= ins and Venules
•D.  Venous Return and Cardiac Output
•MCFP =3D Mean Circulat= ory Filling Pressure
•Estimate of average venular pressure (~7-10 mm Hg)
•Elevated by:
•Ý total blood volume
•Ý venous tone (venoconstriction)
•Decreased by <= /span>
•ß in total blood volume = ;
•ß in venous tone (venodilat= ion) =
•
------=_NextPart_01C9C746.8C206060 Content-Location: file:///C:/21943233/slides-veins_files/slide0073.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" SABS I: Vascular Physiology
SABS I
Veins and Venules
9
IV. Ve= ins and Venules
•<= /span>D.  Venous Return and Cardiac Output&= #13;
<= span style=3D'mso-special-format:bullet;color:#99CCFF;mso-color-index:5;positio= n: absolute;left:-7.32%;top:-.08em;font-size:110%'>•CVP =3D Central Venous Pressure
<= span style=3D'mso-special-format:bullet;color:yellow;position:absolute;left:-6.= 69%; top:-.08em;font-size:110%'>•CVP =3D RAP (right atrial pressure) <= /div>
<= span style=3D'mso-special-format:bullet;color:yellow;position:absolute;left:-6.= 69%; top:-.08em;font-size:110%'>•Normally ~0 mm Hg (range –4 to 30 mm Hg)
<= span style=3D'mso-special-format:bullet;color:yellow;position:absolute;left:-6.= 27%; top:-.08em;font-size:110%'>•CVP is the filling pressure or preload for the heart= 3;
•<= /span> = ;
------=_NextPart_01C9C746.8C206060 Content-Location: file:///C:/21943233/slides-veins_files/slide0074.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" SABS I: Vascular Physiology
SABS I
Veins and Venules
10
<= span style=3D'mso-special-format:bullet;color:#99CCFF;mso-color-index:5;positio= n: absolute;left:-7.32%;top:-.08em;font-size:110%'>•CO vs CVP (Frank-Starling Mechanism)
<= span style=3D'visibility:hidden'>• =
•<= /span> = ;
=
3D14-14
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SABS I
Veins and Venules
11
= Blood Vo= lume and Venous Volume
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