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------=_NextPart_01C9C746.4F775AB0 Content-Location: file:///C:/DE4AB113/slides-capillaries_files/master03.xml Content-Transfer-Encoding: quoted-printable Content-Type: text/xml; charset="utf-8" ------=_NextPart_01C9C746.4F775AB0 Content-Location: file:///C:/DE4AB113/slides-capillaries_files/preview.wmf Content-Transfer-Encoding: base64 Content-Type: image/x-wmf AQAJAAADjGQAAAAAcWQAAAAABQAAAAsCAAAAAAUAAAAMAoACwAMFAAAABwEDAAAAcWQAAEELIADM AGsAoAAAAAAAgALAAwAAAAAoAAAAoAAAAGsAAAABABgAAAAAAKDIAAAAAAAAAAAAAAAAAAAAAAAA YwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAA awAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAA YwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAA awAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAA YwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAA awAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAA 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------=_NextPart_01C9C746.4F775AB0 Content-Location: file:///C:/DE4AB113/slides-capillaries_files/master18.xml Content-Transfer-Encoding: quoted-printable Content-Type: text/xml; charset="utf-8" ------=_NextPart_01C9C746.4F775AB0 Content-Location: file:///C:/DE4AB113/slides-capillaries_files/pres.xml Content-Transfer-Encoding: quoted-printable Content-Type: text/xml; charset="utf-8" ------=_NextPart_01C9C746.4F775AB0 Content-Location: file:///C:/DE4AB113/slides-capillaries_files/slide0097.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" SABS I: Vascular Physiology
SABS I: Vascular Physiology
Steven J. Miller, Ph.D. =
Office: 274-2657
E-Mail: sjmiller@iupui.edu =
http://www.iuvascular.com/U= nthank/teach.html
CAPILLARIES
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SABS I
Capillaries
2
III. Capillaries
A.<= span style=3D'mso-bidi-font-family:"Times New Roman";font-size:88%'>Fundamental Facts
1.Transcapillary exchange is essential for = cell function and survival.
2.Normal tissue function requires selective permeability of capillaries to different solutes.
3.The permeability of capillaries in various tissues must be different for normal organ function to occur.
4.Net water movement across capillary must = be controlled = to maintain proper tissue hydration
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SABS I
Capillaries
3
III. Capillaries
<= span style=3D'font-size:114%'>B.<= span style=3D'mso-bidi-font-family:"Times New Roman";font-size:114%'>Transcapil= lary Exchange of Solute
<= span style=3D'mso-special-format:bullet;color:#99CCFF;mso-color-index:5;positio= n: absolute;left:-8.86%;top:-.08em;font-size:110%'>•Mechanisms for exchange&#= 13;
<= span style=3D'mso-special-format:bullet;color:yellow;position:absolute;left:-8.= 21%; top:-.08em;font-size:110%'>•Diffusion
<= span style=3D'mso-special-format:bullet;color:yellow;position:absolute;left:-8.= 21%; top:-.08em;font-size:110%'>•Bulk flow
<= span style=3D'mso-special-format:bullet;color:yellow;position:absolute;left:-8.= 21%; top:-.08em;font-size:110%'>•Pinocytosis/vesicular transport
<= ![if !vml]>=3D19-15
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SABS I
Capillaries
4
III. Capillaries
<= span style=3D'font-size:114%'>B.<= span style=3D'mso-bidi-font-family:"Times New Roman";font-size:114%'>Transcapil= lary Exchange of Solute
•Factors contributing to rapid diffusiona= l exchange&#= 13;
•Diffusion distance – cells within 20 mm of a capillary&= #13;
<= span style=3D'font-size:117%'>•Large total surface area – 7000 sq. ft.
•Slow rate = of blood flow – 0.1 to 1.0 mm/sec (vs. 40 cm/sec = in aorta
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SABS I
Capillaries
5
III. Capillaries
B.Transcapillary Exchange of Solute
•Diffusion&#= 13;
•for a single capillary: Js=3D[PS(Co-Ci)]/d
•Js =3D solute transfer= red, moles/min
•d =3D distance for diffusion
•(Co-Ci) =3D concentrat= ion gradient from outside to inside of capillary
•<= /span>PS =3D permeability coefficient
–P =3D c= apillary permeability of specific substance
–S =3D c= apillary surface area
•&#= 13;
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SABS I
Capillaries
6
Difference in PS for various solutes due primarily to pathway available for exchange
<= span style=3D'font-weight:bold;visibility:hidden'>B. =
<= span style=3D'visibility:hidden'>•
Substance
Molecular Weight
Molecular Radius (Å)
Specific = Permeability
H2O
18
1.5
28
NaCl
58
2.3
15
Urea
60
2.6
14
Glucose
180
3.7
6
Sucrose
342
4.8
4
Inulin
5,500
12-15
0.3
Myoglobin
17,000
19
0.1
Serum Albumin
67,000
36
0.0001
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