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------=_NextPart_01C9C745.DDF34BB0 Content-Location: file:///C:/6E8AB113/slides-arteries_files/master03.xml Content-Transfer-Encoding: quoted-printable Content-Type: text/xml; charset="utf-8" ------=_NextPart_01C9C745.DDF34BB0 Content-Location: file:///C:/6E8AB113/slides-arteries_files/preview.wmf Content-Transfer-Encoding: base64 Content-Type: image/x-wmf AQAJAAADjGQAAAAAcWQAAAAABQAAAAsCAAAAAAUAAAAMAoACwAMFAAAABwEDAAAAcWQAAEELIADM AGsAoAAAAAAAgALAAwAAAAAoAAAAoAAAAGsAAAABABgAAAAAAKDIAAAAAAAAAAAAAAAAAAAAAAAA YwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAA awAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAA YwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAA awAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAA YwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAA awAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAA 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------=_NextPart_01C9C745.DDF34BB0 Content-Location: file:///C:/6E8AB113/slides-arteries_files/master18.xml Content-Transfer-Encoding: quoted-printable Content-Type: text/xml; charset="utf-8" ------=_NextPart_01C9C745.DDF34BB0 Content-Location: file:///C:/6E8AB113/slides-arteries_files/pres.xml Content-Transfer-Encoding: quoted-printable Content-Type: text/xml; charset="utf-8" ------=_NextPart_01C9C745.DDF34BB0 Content-Location: file:///C:/6E8AB113/slides-arteries_files/slide0096.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" SABS I: Vascular Physiology
SABS I: Vascular Physiology
Steven J. Miller, Ph.D. =
Office: 274-2657
E-Mail: sjmiller@iupui.edu =
http://www.iuvascular.com/U= nthank/teach.html
ARTERIES & ARTERIOLES
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SABS I
Arteries and Arterioles
2
II. Arteries and Arterioles
•A.  Fundamental Facts
1.A high arterial pressure is required to provide = adequate blood flow to the tissues.
2.The pressure in the arteries at a given point in time depends largely on t= he volume of blood in the arteries and arterial compliance.
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II. Arteries and Arterioles
A.<= span style=3D'font-size:113%'>Fundamental Facts
•
3.The total peripheral resistance is determ= ined primarily by the extent to which the arterioles are constricted.
4.Under most conditions, blood flow is matc= hed to the changing metabolic needs of tissues by changes in arteriolar diameter.
5.Arteriolar diameter, total peripheral resistance, and tissue blood flow is determined by local and extrinsi= c control mechanisms.
1.
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Arteries and Arterioles
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II. Arteries and Arterioles
•B.  Pressure in the Arterial System&#= 13;
•1.  Importance of pressure
•If too l= ow: inadequate tissue perfusion ® hypoxia
• ®= necrosi= s, death
•
<= span style=3D'font-family:"CG Times";font-size:88%'>•If too h= igh: vessel damage, stroke, atherosclerosis
<= span style=3D'font-size:88%;visibility:hidden'>1.
•2.  Regulated by the CNS and renal fu= nction
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Arteries and Arterioles
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II. Arteries and Arterioles
•B.  Pressure in the Arterial System&#= 13;
R= 26;3. Effect= of compliance (C )  and volume (= V) on pressure
•C=3DDV/ D= P
•
•Compliance decreases with age
•
• DP=3DD= V/ C
•4. Interm= ittent input to continuous output
•
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II. Arteries and Arterioles
•B.  Pressure in the Arterial System
•5. Arterial pressures
•Systolic pressure (Psys): highest pressure during ventricular ejection or systole
••Diastolic pressure(Pdias): lowest pressure during ventricular relaxation or diastole
•&= #13;
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test
Overview
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Arter= ial Pressures
=3D19-2
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SABS I
Arteries and Arterioles
8
II. Arteries and Arterioles
•B.  Pressure in the Arterial System&#= 13;
•5. Arterial pressures
•pulse pres= sure (Pp): Psys- Pdias
•
Mean arter= ial pressure (MAP): average pressure over one or more complete heart= cycles = 3;
•
<= ![if !vml]>=3D19-3
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aQACAgA7 ------=_NextPart_01C9C745.DDF34BB0 Content-Location: file:///C:/6E8AB113/slides-arteries_files/slide0035.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" SABS I: Vascular Physiology
SABS I
Arteries and Arterioles
9
II. Arteries and Arterioles
•B.  Pressure in the Arterial System
•6. Measurement and estimation of arterial pressures <= /span>
<= span style=3D'mso-special-format:bullet;color:#99CCFF;mso-color-index:5;positio= n: absolute;left:-7.04%;top:-.08em;font-size:110%'>•Direct measurement by art= erial cannulation
<= span style=3D'mso-special-format:bullet;color:yellow;position:absolute;left:-6.= 85%; top:-.08em;font-size:110%'>• invasive&= #13;
<= span style=3D'mso-special-format:bullet;color:yellow;position:absolute;left:-6.= 85%; top:-.08em;font-size:110%'>• requires = use of transducer and amplifiers
<= span style=3D'mso-special-format:bullet;color:yellow;position:absolute;left:-6.= 85%; top:-.08em;font-size:110%'>• most accurate
•&= #13;
------=_NextPart_01C9C745.DDF34BB0 Content-Location: file:///C:/6E8AB113/slides-arteries_files/slide0036.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" SABS I: Vascular Physiology
SABS I
Arteries and Arterioles
10
II. Arteries and Arterioles
•B.  Pressure in the Arterial System&#= 13;
•6. Measur= ement and estimation of arterial pressures
•Auscultatory method
non-invasive <= /span>
can be done with automated system
•accuracy within 10% of di= rect measurements when properly performed
•Subject to considerable e= rror due to anxiety (white