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------=_NextPart_01C9C745.DDF34BB0 Content-Location: file:///C:/6E8AB113/slides-arteries_files/master03.xml Content-Transfer-Encoding: quoted-printable Content-Type: text/xml; charset="utf-8" ------=_NextPart_01C9C745.DDF34BB0 Content-Location: file:///C:/6E8AB113/slides-arteries_files/preview.wmf Content-Transfer-Encoding: base64 Content-Type: image/x-wmf AQAJAAADjGQAAAAAcWQAAAAABQAAAAsCAAAAAAUAAAAMAoACwAMFAAAABwEDAAAAcWQAAEELIADM AGsAoAAAAAAAgALAAwAAAAAoAAAAoAAAAGsAAAABABgAAAAAAKDIAAAAAAAAAAAAAAAAAAAAAAAA YwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAA awAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAA YwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAA awAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAA YwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAA awAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAAYwAAawAA 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------=_NextPart_01C9C745.DDF34BB0 Content-Location: file:///C:/6E8AB113/slides-arteries_files/master18.xml Content-Transfer-Encoding: quoted-printable Content-Type: text/xml; charset="utf-8" ------=_NextPart_01C9C745.DDF34BB0 Content-Location: file:///C:/6E8AB113/slides-arteries_files/pres.xml Content-Transfer-Encoding: quoted-printable Content-Type: text/xml; charset="utf-8" ------=_NextPart_01C9C745.DDF34BB0 Content-Location: file:///C:/6E8AB113/slides-arteries_files/slide0096.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" SABS I: Vascular Physiology
SABS I: Vascular Physiology
Steven J. Miller, Ph.D. =
Office: 274-2657
E-Mail: sjmiller@iupui.edu =
http://www.iuvascular.com/U= nthank/teach.html
ARTERIES & ARTERIOLES
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SABS I
Arteries and Arterioles
2
II. Arteries and Arterioles
•A.  Fundamental Facts
1.A high arterial pressure is required to provide = adequate blood flow to the tissues.
2.The pressure in the arteries at a given point in time depends largely on t= he volume of blood in the arteries and arterial compliance.
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II. Arteries and Arterioles
A.<= span style=3D'font-size:113%'>Fundamental Facts
•
3.The total peripheral resistance is determ= ined primarily by the extent to which the arterioles are constricted.
4.Under most conditions, blood flow is matc= hed to the changing metabolic needs of tissues by changes in arteriolar diameter.
5.Arteriolar diameter, total peripheral resistance, and tissue blood flow is determined by local and extrinsi= c control mechanisms.
1.
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Arteries and Arterioles
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II. Arteries and Arterioles
•B.  Pressure in the Arterial System&#= 13;
•1.  Importance of pressure
•If too l= ow: inadequate tissue perfusion ® hypoxia
• ®= necrosi= s, death
•
<= span style=3D'font-family:"CG Times";font-size:88%'>•If too h= igh: vessel damage, stroke, atherosclerosis
<= span style=3D'font-size:88%;visibility:hidden'>1.
•2.  Regulated by the CNS and renal fu= nction
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Arteries and Arterioles
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II. Arteries and Arterioles
•B.  Pressure in the Arterial System&#= 13;
R= 26;3. Effect= of compliance (C )  and volume (= V) on pressure
•C=3DDV/ D= P
•
•Compliance decreases with age
•
• DP=3DD= V/ C
•4. Interm= ittent input to continuous output
•
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II. Arteries and Arterioles
•B.  Pressure in the Arterial System
•5. Arterial pressures
•Systolic pressure (Psys): highest pressure during ventricular ejection or systole
••Diastolic pressure(Pdias): lowest pressure during ventricular relaxation or diastole
•&= #13;
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test
Overview
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Arter= ial Pressures
=3D19-2
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SABS I
Arteries and Arterioles
8
II. Arteries and Arterioles
•B.  Pressure in the Arterial System&#= 13;
•5. Arterial pressures
•pulse pres= sure (Pp): Psys- Pdias
•
Mean arter= ial pressure (MAP): average pressure over one or more complete heart= cycles = 3;
•
<= ![if !vml]>=3D19-3
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SABS I
Arteries and Arterioles
9
II. Arteries and Arterioles
•B.  Pressure in the Arterial System
•6. Measurement and estimation of arterial pressures <= /span>
<= span style=3D'mso-special-format:bullet;color:#99CCFF;mso-color-index:5;positio= n: absolute;left:-7.04%;top:-.08em;font-size:110%'>•Direct measurement by art= erial cannulation
<= span style=3D'mso-special-format:bullet;color:yellow;position:absolute;left:-6.= 85%; top:-.08em;font-size:110%'>• invasive&= #13;
<= span style=3D'mso-special-format:bullet;color:yellow;position:absolute;left:-6.= 85%; top:-.08em;font-size:110%'>• requires = use of transducer and amplifiers
<= span style=3D'mso-special-format:bullet;color:yellow;position:absolute;left:-6.= 85%; top:-.08em;font-size:110%'>• most accurate
•&= #13;
------=_NextPart_01C9C745.DDF34BB0 Content-Location: file:///C:/6E8AB113/slides-arteries_files/slide0036.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" SABS I: Vascular Physiology
SABS I
Arteries and Arterioles
10
II. Arteries and Arterioles
•B.  Pressure in the Arterial System&#= 13;
•6. Measur= ement and estimation of arterial pressures
•Auscultatory method
non-invasive <= /span>
can be done with automated system
•accuracy within 10% of di= rect measurements when properly performed
•Subject to considerable e= rror due to anxiety (white coat hypertension) or improper methodology
••
------=_NextPart_01C9C745.DDF34BB0 Content-Location: file:///C:/6E8AB113/slides-arteries_files/slide0106.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" SABS I: Vascular Physiology
test
Overview
11
Auscul= atory Method
=3D19-4
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SABS I
Arteries and Arterioles
12
II. Arteries and Arterioles
•B.  Pressure in the Arterial System
•6. Measurement and estimation of arterial pressures <= /span>
•Estimation of mean arteri= al pressure (MAP)
<= span style=3D'mso-special-format:bullet;color:yellow;position:absolute;left:-6.= 85%; top:-.08em;font-size:110%'>• P<= span style=3D'mso-bidi-font-family:"Times New Roman";font-size:67%;position:rel= ative; top:.37em;mso-text-raise:-25%'>dias+1/3(Pp)
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<= span style=3D'mso-special-format:bullet;color:yellow;position:absolute;left:-6.= 85%; top:-.08em;font-size:110%'>• ~2/3 of h= eart cycle occurs during diastole
•
•&= #13;
------=_NextPart_01C9C745.DDF34BB0 Content-Location: file:///C:/6E8AB113/slides-arteries_files/slide0038.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" SABS I: Vascular Physiology
SABS I
Arteries and Arterioles
13
II. Arteries and Arterioles
•C.  Total Peripheral Resistance <= /span>
1.Definition: total vascular resistance of the peripheral circulation (aorta back to heart)
2.Major site of resistance: arterioles and small arteries
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•&= #13;
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•C.  Total Peripheral Resistance
<= span style=3D'mso-special-format:"numbullet3\,1";color:white;mso-color-index:3; position:absolute;left:-7.72%;top:-.08em;font-size:110%'>1.Arteriolar tone: effect on resistance
<= span style=3D'visibility:hidden'>3. =
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•&= #13;
 r
 r4
R
Control
1.0
1.00
1.0
50% constriction
0.5
0.06
16
50% dilation
1.5
5.06
0.2
From their normal resting state, the resistance vessels (small arteries and arterioles) can both dilate and constrict.  Their changes in diameter can ha= ve large effects upon resistance and blood flow.
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II. Arteries and Arterioles
•D.  Short-term Regulation of Arteriolar Resistance
<= span style=3D'mso-special-format:"numbullet3\,1";color:white;mso-color-index:3; position:absolute;left:-7.72%;top:-.08em;font-size:110%'>1.Examples
•Autoregulation:  the maintenance of nearly = constant organ blood flow= over a wide range of perfusion pressures
•Reactive hyperemia: incre= ase in blood flow after a period of deprivation
<= span style=3D'visibility:hidden'>1. =
•
•&= #13;
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II. Arteries and Arterioles
•D.  Short-term Regulation of Arteriolar Resistance
<= span style=3D'font-size:88%'>1.Examples
•Functional hyperemia:  increase in blood flow related to an incre= ase in tissue metabolism
<= span style=3D'font-size:86%'>•Skeletal mu= scle: 8-20X increase with exercise
•Intestine: 1.5-2.0X increase during absorption (postprandial hyperemia)&= #13;
<= span style=3D'font-size:86%'>•Cardiac mus= cle: 5-6X increase
<= span style=3D'font-size:86%'>•Cerebral bl= ood flow can be increased 20-40%
•
•
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II. Arteries and Arterioles
•D.  Short-term Regulation of Arteriolar Resistance
<= span style=3D'mso-special-format:"numbullet3\,1";color:white;mso-color-index:3; position:absolute;left:-7.72%;top:-.08em;font-size:110%'>1.Examples
<= span style=3D'mso-special-format:bullet;color:yellow;position:absolute;left:-7.= 72%; top:-.08em;font-size:110%'>•Dilation of collateral arteries
•Increase in skin blood flow during heat stress
•
•As tissue needs cha= nge, how are transportation and exchange altered?
•
•&= #13;
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II. Arteries and Arterioles
•D.  Short-term Regulation of Arteriol= ar Resistance
<= span style=3D'font-size:88%'>2.Major control mechanisms
•Local control:  regulation at the level of tissue= and vessel = ;
•Extrinsic control: regulation by mechanisms/factors external to the local tissue
<= span style=3D'font-size:86%'>•Neural (*primarily by the sympathetic nervous system)
<= span style=3D'font-size:86%'>•Humoral = 3;
•
•
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II. Arteries and Arterioles
•D.  Short-term Regulation of Arteriol= ar Resistance
D.<= /span>
•Local Control Mechanisms&= #13;
•Myogenic vascular control: response of the vessel to a change in distending pressure
•Ca+2 channels in vascular smooth muscle cells are sensitive to stretch
•­P ® activation, vasoconstriction
•¯P ® relaxation, vasodilation=
•
•
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test
Overview
20
Myogenic Vascular Control
=3D19-9
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SABS I
Arteries and Arterioles
21
II. Arteries and Arterioles
•D.  Short-term Regulation of Arteriolar Resistance
•Local Control Mechanisms
•Metabolic vascular contro= l: a change in arteriolar diameter associated with a change in metabolism.
<= span style=3D'mso-special-format:bullet;color:yellow;position:absolute;left:-5.= 79%; top:-.08em;font-size:110%'>•­<= span style=3D'mso-bidi-font-family:"Times New Roman"'>metabolism ® ­ adenosine, ­ K+, ­ CO2, ­ H+, ¯2
<= span style=3D'mso-special-format:bullet;color:yellow;position:absolute;left:-5.= 66%; top:-.08em;font-size:110%'>•¯= metabolism ® ¯¯ K+, ¯2, ¯ H+, ­ O2
•
•
------=_NextPart_01C9C745.DDF34BB0 Content-Location: file:///C:/6E8AB113/slides-arteries_files/slide0108.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" SABS I: Vascular Physiology
test
Overview
22
Metabo= lic Vascular Control
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SABS I
Arteries and Arterioles
23
II. Arteries and Arterioles
•D.  Short-term Regulation of Arteriolar Resistance
•Local Control Mechanisms
•Flow-dependent diameter changes:
•­shear stress ® ­Nitric oxide (NO) production (Endothelium)
<= span style=3D'mso-special-format:bullet;color:yellow;position:absolute;left:-5.= 46%; top:-.08em;font-size:110%'>•­<= span style=3D'mso-bidi-font-family:"Times New Roman"'>NO ® ­cGMP production ® smooth muscle relaxation
<= span style=3D'visibility:hidden'>• =
•
•&= #13;
An increase in flow leads to elevation calcium ion concentration in endothel= ial cell.  The increased calcium activates nitric oxide synthase (NOS) and more nitric oxide (NO) is produ= ced.  The NO diffuses to the smooth mu= scle and increases cGMP production, resulting in vasodilation (relaxation of t= he vascular smooth muscle).
------=_NextPart_01C9C745.DDF34BB0 Content-Location: file:///C:/6E8AB113/slides-arteries_files/slide0109.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" SABS I: Vascular Physiology
test
Overview
24
Flow-d= ependent Vascular Control
=3D5-9
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quoted-printable Content-Type: text/html; charset="us-ascii" SABS I: Vascular Physiology
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•D.  Short-term Regulation of Arteriol= ar Resistance
•Local Control Mechanisms&= #13;
•Chemical mediators of inflammation
Histamine
Bradykinin
Serotonin
Prostaglandins
Leukotrienes <= /span>
• =
• =
•
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II. Arteries and Arterioles
•D.  Short-term Regulation of Arteriolar Resistance
•Extrinsic Control Mechanisms
<= span style=3D'font-size:88%'>•Neural Cont= rol
<= span style=3D'font-size:86%'>•Innervation: Sympathetic nervous system
•Exceptions: vessels in he= art and brain have limited if any innervation
•
•(Note: Innervation of ves= sels by parasympathetic neurons  <= /span>occurs only in a few orga= ns and has minimal effect on total peripheral resistance)
<= span style=3D'font-size:83%;visibility:hidden'>••
•
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II. Arteries and Arterioles
•D.  Short-term Regulation of Arteriol= ar Resistance
•Extrinsic Control Mechanisms
•Neural Control
Neurotransmitter:  norepinephrine =
Receptors: alpha adrenerg= ic receptors
•Basal Tone:  sympathetic nerve activity can be= increased and decreased f= rom resting state; resulting in vasoconstriction and vasodilation.
•
For alpha1 adrenoceptors, epinephrine is approximately equipotent = with norepinephrine.
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•D.  Short-term Regulation of Arteriolar Resistance
•Extrinsic Control Mechanisms
<= span style=3D'mso-special-format:bullet;color:#99CCFF;mso-color-index:5;positio= n: absolute;left:-7.72%;top:-.08em;font-size:110%'>•Hormonal Control
•Renin-angiotensin system:=   angiotensin II is one of <= /span>the most potent vasoconstrictors.  This syste= m can be important in high blood pressure.
•
•
•&= #13;
------=_NextPart_01C9C745.DDF34BB0 Content-Location: file:///C:/6E8AB113/slides-arteries_files/slide0052.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" SABS I: Vascular Physiology
SABS I
Arteries and Arterioles
29
II. Arteries and Arterioles
•D.  Short-term Regulation of Arteriolar Resistance
•Extrinsic Control Mechanisms
<= span style=3D'font-size:88%'>•Hormonal Co= ntrol
<= span style=3D'font-size:86%'>•Epinephrine=
•Released from the adrenal medula upon stimulation of the sympathetic nervous system.
•Receptors: beta adrenergic receptors located primarily on vessels in heart, skeletal muscle, and liver.
•Receptor activation resul= ts in relaxation/vasodilation of arterioles and venules
Beta1 adrenoceptors are found primarily on cardiac muscle and modulate the rate= and strength of contraction.  Bo= th norepinephrine and epinephrine can bind to these receptors with approxima= tely equal affinity.
Beta2 adrenoceptors are found in most other tissues including blood vessels.  These receptors are much, much m= ore sensitive to epinephrine than norepinephrine.

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test
Overview
30
Recept= or-mediated Vascular Control
=3D19-11
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SABS I
Arteries and Arterioles
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II. Arteries and Arterioles
•Summary of effects of alpha and beta adrenergic re= ceptor activation in res= ponse to increased sympathetic nerve activity (SNA)
•­SNA ® ­ release of norepinephrine (NE) and = epinephrine (Epi)
•­NE ® vasoconstriction and ­ resistanc= e in most organs (not = heart or brain)
•­Epi ® vasodilation in heart and opposes activity of NE in skeletal muscle
<= span style=3D'font-size:83%;visibility:hidden'>•
------=_NextPart_01C9C745.DDF34BB0 Content-Location: file:///C:/6E8AB113/slides-arteries_files/slide0054.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" SABS I: Vascular Physiology
SABS I
Arteries and Arterioles
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II. Arteries and Arterioles
•E.  L= ong-term Regulation of Arteriolar Resistance
1.<= span style=3D'mso-bidi-font-family:"Times New Roman";font-size:88%'>Changes in = tissue vascularity (number of vessels)
•Angiogenesis: formation of new capillaries
•Arteriolar rarefaction: loss of arterioles
•Arteriolar proliferation
2.<= span style=3D'mso-bidi-font-family:"Times New Roman";font-size:88%'>Changes in = vessel size (inner diameter)
•Arteriogenesis: structural development of existing vessels to become new or larger arteries.
•Collateralization: structural development= of existing vessels which provide alternative blood supply route af= ter occlusion of another artery
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From their= normal resting state, the resistance vessels (small arteries and arterioles) can = both dilate and constrict.  Their changes in diameter can have large effects upon resistance and blood flow.=
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An increas= e in flow leads to elevation calcium ion concentration in endothelial cell.  The increased calcium activates n= itric oxide synthase (NOS) and more nitric oxide (NO) is produced.  The NO diffuses to the smooth mus= cle and increases cGMP production, resulting in vasodilation (relaxation of th= e vascular smooth muscle).
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For alpha<= span style=3D'font-size:67%;position:relative;top:.37em;mso-text-raise:-25%'>1<= /span> adrenoceptors, epinephrine is approximately equipotent with norepinephrine.
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Beta1<= /span> adrenoceptors are found primarily = on cardiac muscle and modulate the rate and strength of contraction.  Both norepinephrine and epinephri= ne can bind to these receptors with approximately equal affinity.
Beta2<= /span> adrenoceptors are found in most ot= her tissues including blood vessels.  These receptors are much, much more sensitive to epinephrine than norepinephrine= .
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FULLSCR_HREF = : FULLSCR_HREF+"#"+GetHrefObj(gCurSld).mSldHref; if(PPTNav.event.ctrlKey) { var w =3D (window.screen.availWidth * 1.0) / 2.0 var h =3D w * (PPTSld.g_origH * 1.0) / PPTSld.g_origW win =3D window.open( MHTMLPrefix+href,null,"toolbar=3D0,resizable=3D1,top= =3D0,left=3D0," + "width=3D"+ w + ",height=3D" + h ); if( win.document.body && PPTSld.g_animUseRuntime ) win.document.body.PPTSldFrameset=3Dwindow; } else { win =3D window.open( MHTMLPrefix+href,null,"fullscreen=3Dyes" ); if( win.document.body && PPTSld.g_animUseRuntime ) win.document.body.PPTSldFrameset=3Dwindow; } } function ToggleVNarration() { rObj=3DPPTSld.document.all("NSPlay") if( rObj && !PPTSld.g_animUseRuntime ) { if( (rObj.playState =3D=3D 1)||(rObj.playState =3D=3D 0) ) rObj.Play() else if( rObj.playState =3D=3D 2 ) rObj.Pause() else return; } else if( PPTSld.g_animUseRuntime ) { narObj =3D PPTSld.document.all("narrationID") if( narObj ) narObj.togglePause() } } function GetCurSldNum() { obj=3DGetHrefObj(gCurSld) if( obj.mOrigVis =3D=3D 1 ) return obj.mSldIdx else return gCurSld } function GetNumSlds() { if( GetHrefObj(gCurSld).mOrigVis =3D=3D 1 ) return GetSldList().mNumVisSlds; else return GetSldList().mList.length } function GetSldNum( href ) { for(ii=3D0; ii 1 ) PopSldList(); else if( !IsFramesMode() ) { if( gLoopCont ) GoToFirst() else EndShow() } } function GoToPrevSld() { ii=3DgCurSld-1 if( ii > 0 ) { obj=3DGetHrefObj(ii) while ( obj && ( obj.mVis =3D=3D 0 ) && ( ii>0 ) ) obj=3DGetHrefObj(--ii) if( ii =3D=3D 0 ) ii=3D1 GoToSldNum(ii) } } function GoToFirst(){ GoToSld( GetHrefObj(1).mSldHref ) } function GoToLast() { ii=3DGetSldList().mList.length if( ii !=3D gCurSld ) GoToSld( GetHrefObj(ii).mSldHref ) } function GoToSldNum( num ) { if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue obj =3D GetHrefObj( num ) obj.mVis=3D1 gPrevSld=3DgCurSld gCurSld =3D num; PPTSld.location.replace(MHTMLPrefix+obj.mSldHref) if( IsFramesMode() ) { UpdNavPane(); UpdOtlPane(); UpdNtsPane() } } function GoToSld( href ) { if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue GetHrefObj( GetSldNum(href) ).mVis=3D1 PPTSld.location.replace(MHTMLPrefix+href) } function SldUpdated( id ) { if( id =3D=3D GetHrefObj(gCurSld).mSldHref ) return gPrevSld=3DgCurSld gCurSld=3DGetSldNum(id) if( IsFramesMode() ) { UpdNavPane(); UpdOtlPane(); UpdNtsPane() } } function PrevSldViewed(){ GoToSld( GetHrefObj(gPrevSld).mSldHref ) } function HasPrevSld() { return ( gIsEndShow || ( gCurSld !=3D 1 && GetHrefO= bj( gCurSld-1 ).mVis =3D=3D 1 )||( GetCurSldNum() > 1 ) ) } function HasNextSld() { return (GetCurSldNum() !=3D GetNumSlds()) } function CloseWindow() { if( HideMenu() ) return; var event =3D PPTSld.event; if( !IsFramesMode() && event && (event.keyCode=3D=3D27 || event.keyCode=3D= =3D32 || event.type=3D=3D"click" ) ) window.close( self ); CatchNumKeys( self, event ); } function Unload() { gIsEndShow=3D0; } function SetupEndShow() { gIsEndShow=3D1; PPTSld.document.body.scroll=3D"no"; PPTSld.document.onkeypress=3DCloseWindow; PPTSld.document.onclick=3DCloseWindow; PPTSld.document.oncontextmenu=3D_CM; } function EndShow() { if( IsFramesMode() ) return if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue doc=3DPPTSld.document var dir =3D doc.body.dir if( dir !=3D "rtl" ) dir =3D "ltr"; doc.open() doc.writeln('


' + ENDSHOW_MESG + '

') doc.close() } function SetSldVisited(){ GetSldList().mList[gCurSld-1].mVisited=3Dtrue } function IsSldVisited(){ return GetSldList().mList[gCurSld-1].mVisited } function hrefList( sldHref, visible, advDelay, advClk ) { this.mSldHref=3D this.mNtsHref =3D sldHref this.mOrigVis=3D this.mVis =3D visible this.mVisited=3D false this.mAdvDelay=3D advDelay this.mAdvOnClk=3D advClk } function SldList(arr,curSld,fEnd) { this.mCurSld =3D curSld; this.mList =3D new Array(); var idx =3D 1; for(ii=3D0;ii 0) { PushSldList(sldList,fEnd); gCurSld =3D 1; } else if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue } function PushSldList(arr,fEnd) { var ii =3D gSldStack.length; gSldStack[ii] =3D new SldList(arr,gCurSld,fEnd); GoToSld( gSldStack[ii].mList[0].mSldHref ); } function PopSldList() { if (gSldStack[gSldStack.length-1].fEndShow) EndShow() else { gCurSld =3D gSldStack[gSldStack.length-1].mCurSld; gSldStack[gSldStack.length-1] =3D null; gSldStack.length--; var sldList =3D gSldStack[gSldStack.length-1]; GoToSld( sldList.mList[gCurSld - 1].mSldHref ); } } var custShowList=3Dnew Array(); function ImgBtn( oId,bId,w,action ) { var t=3Dthis t.Perform =3D _IBP t.SetActive =3D _IBSetA t.SetInactive=3D _IBSetI t.SetPressed =3D _IBSetP t.SetDisabled=3D _IBSetD t.Enabled =3D _IBSetE t.ChangeIcon =3D null t.UserAction =3D action t.ChgState =3D _IBUI t.mObjId =3D oId t.mBorderId=3D bId t.mWidth =3D w t.mIsOn =3D t.mCurState =3D 0 } function _IBSetA() { if( this.mIsOn ) { obj=3Dthis.ChgState( gHiliteClr,gShadowClr,2 ) obj.style.posTop=3D0 } } function _IBSetI() { if( this.mIsOn ) { obj=3Dthis.ChgState( gFaceClr,gFaceClr,1 ) obj.style.posTop=3D0 } } function _IBSetP() { if( this.mIsOn ) { obj=3Dthis.ChgState( gShadowClr,gHiliteClr,2 ) obj.style.posLeft+=3D1; obj.style.posTop+=3D1 } } function _IBSetD() { obj=3Dthis.ChgState( gFaceClr,gFaceClr,0 ) obj.style.posTop=3D0 } function _IBSetE( state ) { var t=3Dthis GetObj( t.mBorderId ).style.visibility=3D"visible" if( state !=3D t.mIsOn ) { t.mIsOn=3Dstate if( state ) t.SetInactive() else t.SetDisabled() } } function _IBP() { var t=3Dthis if( t.mIsOn ) { if( t.UserAction !=3D null ) t.UserAction() if( t.ChangeIcon ) { obj=3DGetObj(t.mObjId) if( t.ChangeIcon() ) obj.style.posLeft=3Dobj.style.posLeft+(t.mCurState-4)*t.mWidth else obj.style.posLeft=3Dobj.style.posLeft+(t.mCurState-0)*t.mWidth } t.SetActive() } } function _IBUI( clr1,clr2,nextState ) { var t=3Dthis SetBorder( GetObj( t.mBorderId ),clr1,clr2 ) obj=3DGetObj( t.mObjId ) obj.style.posLeft=3Dobj.style.posLeft+(t.mCurState-nextState)*t.mWidth-obj= .style.posTop t.mCurState=3DnextState return obj } function TxtBtn( oId,oeId,action,chkState ) { var t=3Dthis t.Perform =3D _TBP t.SetActive =3D _TBSetA t.SetInactive=3D _TBSetI t.SetPressed =3D _TBSetP t.SetDisabled=3D _TBSetD t.SetEnabled =3D _TBSetE t.GetState =3D chkState t.UserAction =3D action t.ChgState =3D _TBUI t.mObjId =3D oId t.m_elementsId=3D oeId t.mIsOn =3D 1 } function _TBSetA() { var t=3Dthis if( t.mIsOn && !t.GetState() ) t.ChgState( gHiliteClr,gShadowClr,0,0 ) } function _TBSetI() { var t=3Dthis if( t.mIsOn && !t.GetState() ) t.ChgState( gFaceClr,gFaceClr,0,0 ) } function _TBSetP() { if( this.mIsOn ) this.ChgState( gShadowClr,gHiliteClr,1,1 ) } function _TBSetD() { this.ChgState( gFaceClr,gFaceClr,0,0 ) this.mIsOn =3D 0 } function _TBSetE() { var t=3Dthis if( !t.GetState() ) t.ChgState( gFaceClr,gFaceClr,0,0 ) else t.ChgState( gShadowClr,gHiliteClr,1,1 ) t.mIsOn =3D 1 } function _TBP() { var t=3Dthis if( t.mIsOn ) { if( t.UserAction !=3D null ) t.UserAction() if( !t.GetState ) return if( t.GetState() ) t.SetPressed() else t.SetActive() } } function _TBUI( clr1,clr2,lOffset,tOffset ) { SetBorder( GetObj( this.mObjId ),clr1,clr2 ) Offset( GetObj( this.m_elementsId ),lOffset,tOffset ) } function Offset( obj, top, left ){ obj.style.top=3Dtop; obj.style.left=3Dle= ft } function SetBorder( obj, upperLeft, lowerRight ) { s=3Dobj.style; s.borderStyle =3D "solid" s.borderWidth =3D 1 s.borderLeftColor =3D s.borderTopColor =3D upperLeft s.borderBottomColor=3D s.borderRightColor =3D lowerRight } function GetBtnObj(){ return gBtnArr[window.event.srcElement.id] } function BtnOnOver(){ b=3DGetBtnObj(); if( b !=3D null ) b.SetActive() } function BtnOnDown(){ b=3DGetBtnObj(); if( b !=3D null ) b.SetPressed() } function BtnOnOut(){ b=3DGetBtnObj(); if( b !=3D null ) b.SetInactive() } function BtnOnUp() { b=3DGetBtnObj() if( b !=3D null ) b.Perform() else Upd() } function GetNtsState(){ return parent.gNtsOpen } function GetOtlState(){ return parent.gOtlOpen } function GetOtlTxtState(){ return parent.gOtlTxtExp } function NtsBtnSetFlag( fVal ) { s=3Ddocument.all.item( this.m_flagId ).style s.display=3D"none" if( fVal ) s.display=3D"" else s.display=3D"none" } function _BSetA_Border(){ b =3D gBtnArr[this.mObjId]; if( b !=3D null ) b.S= etActive() } function _BSetI_Border(){ b =3D gBtnArr[this.mObjId]; if( b !=3D null ) b.S= etInactive() } function _BSetP_Border(){ b =3D gBtnArr[this.mObjId]; if( b !=3D null ) b.S= etPressed() } function _BSetA_BorderImg() { b =3D gBtnArr[this.mBorderId] if( b !=3D null && this.mIsOn && !b.GetState() ) { obj=3Dthis.ChgState( gHiliteClr,gShadowClr,2 ) obj.style.posTop=3D0 } } function _BSetI_BorderImg() { b =3D gBtnArr[this.mBorderId] if( b !=3D null && this.mIsOn && !b.GetState() ) { obj=3Dthis.ChgState( gFaceClr,gFaceClr,1 ) obj.style.posTop=3D0 } } var gHiliteClr=3D"THREEDHIGHLIGHT",gShadowClr=3D"THREEDSHADOW",gFaceClr=3D"= THREEDFACE" var gBtnArr =3D new Array() gBtnArr["nb_otl"] =3D new TxtBtn( "nb_otl","nb_otlElem",parent.ToggleOtlPan= e,GetOtlState ) gBtnArr["nb_otlElem"] =3D new TxtBtn( "nb_otl","nb_otlElem",parent.ToggleOt= lPane,GetOtlState ) gBtnArr["nb_nts"] =3D new ImgBtn( "nb_nts","nb_ntsBorder",10,parent.ToggleN= tsPane ) gBtnArr["nb_nts"].SetActive =3D _BSetA_BorderImg; gBtnArr["nb_nts"].SetInactive =3D _BSetI_BorderImg; gBtnArr["nb_ntsBorder"] =3D new TxtBtn( "nb_ntsBorder","nb_ntsElem",parent.= ToggleNtsPane,GetNtsState ) gBtnArr["nb_ntsElem"] =3D new TxtBtn( "nb_ntsBorder","nb_ntsElem",parent.To= ggleNtsPane,GetNtsState ) gBtnArr["nb_prevBorder"] =3D gBtnArr["nb_prev"]=3D new ImgBtn( "nb_prev","n= b_prevBorder",30,parent.GoToPrevSld ) gBtnArr["nb_nextBorder"] =3D gBtnArr["nb_next"]=3D new ImgBtn( "nb_next","n= b_nextBorder",30,parent.GoToNextSld ) gBtnArr["nb_sldshw"]=3D new ImgBtn( "nb_sldshw","nb_sldshwBorder",18,parent= .FullScreen ) gBtnArr["nb_sldshwBorder"] =3D new TxtBtn( "nb_sldshw","nb_sldshwBorder",pa= rent.FullScreen,null ) gBtnArr["nb_sldshwBorder"].SetActive =3D _BSetA_Border; gBtnArr["nb_sldshwBorder"].SetInactive =3D _BSetI_Border; gBtnArr["nb_sldshwText"] =3D new TxtBtn( "nb_sldshw","nb_sldshwText",parent= .FullScreen,null ) gBtnArr["nb_sldshwText"].SetActive =3D _BSetA_Border; gBtnArr["nb_sldshwText"].SetInactive =3D _BSetI_Border; gBtnArr["nb_voice"] =3D gBtnArr["nb_voiceBorder"] =3D new ImgBtn( "nb_voice= ","nb_voiceBorder",18,parent.ToggleVNarration ) gBtnArr["nb_otlTxtBorder"] =3D gBtnArr["nb_otlTxt"]=3D new ImgBtn( "nb_otlT= xt","nb_otlTxtBorder",23,parent.ToggleOtlText ) gBtnArr["nb_ntsBorder"].m_flagId=3D "nb_nts" gBtnArr["nb_ntsBorder"].SetFlag =3D NtsBtnSetFlag gBtnArr["nb_otlTxt"].ChangeIcon=3D GetOtlTxtState var sNext=3D"Next",sPrev=3D"Previous",sEnd=3D"End Show",sFont=3D"Arial",sAr= row=3D"Arrow",sFreeform=3D"Freeform",sRect=3D"Rectangle",sOval=3D"Oval" function ShowMenu() { BuildMenu(); var doc=3DPPTSld.document.body,x=3DPPTSld.event.clientX+doc.scrollLeft,y= =3DPPTSld.event.clientY+doc.scrollTop m =3D PPTSld.document.all.item("ctxtmenu") m.style.pixelLeft=3Dx if( (x+m.scrollWidth > doc.clientWidth)&&(x-m.scrollWidth > 0) ) m.style.pixelLeft=3Dx-m.scrollWidth m.style.pixelTop=3Dy if( (y+m.scrollHeight > doc.clientHeight)&&(y-m.scrollHeight > 0) ) m.style.pixelTop=3Dy-m.scrollHeight m.style.display=3D"" } function _CM() { if( !parent.IsFullScrMode() ) return; if(!PPTSld.event.ctrlKey) { ShowMenu() return false } else HideMenu() } function BuildMenu() { if( PPTSld.document.all.item("ctxtmenu") ) return var mObj=3DCreateItem( PPTSld.document.body ) mObj.id=3D"ctxtmenu" mObj.style.visibility=3D"hidden" var s=3DmObj.style s.position=3D"absolute" s.cursor=3D"default" s.width=3D"120px" SetCMBorder(mObj,"menu","black") var iObj=3DCreateItem( mObj ) SetCMBorder( iObj, "threedhighlight","threedshadow" ) iObj.style.padding=3D2 CreateMenuItem( iObj,sNext,M_GoNextSld,M_True ) CreateMenuItem( iObj,sPrev,M_GoPrevSld,M_HasPrevSld ) CreateSeparator( iObj ) CreateMenuItem( iObj,sEnd,M_End,M_True ) mObj.style.visibility=3D"visible" } function Cancel() { window.event.cancelBubble=3Dtrue; window.event.returnVa= lue=3Dfalse } function Highlight() { ChangeClr("activecaption","threedhighlight") } function Deselect() { ChangeClr("threedface","menutext") } function Perform() { e=3DPPTSld.event.srcElement if( e.type=3D=3D"menuitem" && e.IsActive() ) e.Action() else PPTSld.event.cancelBubble=3Dtrue } function ChangeClr( bg,clr ) { e=3DPPTSld.event.srcElement if( e.type=3D=3D"menuitem" && e.IsActive() ) { e.style.backgroundColor=3Dbg e.style.color=3Dclr } } function M_HasPrevSld() { return( parent.HasPrevSld() ) } function M_GoNextSld() { if( gIsEndShow ) M_End(); 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charset="us-ascii" SABS I: Vascular Physiology ------=_NextPart_01C9C745.DDF34BB0 Content-Location: file:///C:/6E8AB113/slides-arteries_files/outline.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii"
 No= tes
Slide Show
Outline
= = = = = = = = ------=_NextPart_01C9C745.DDF34BB0 Content-Location: file:///C:/6E8AB113/slides-arteries_files/filelist.xml Content-Transfer-Encoding: quoted-printable Content-Type: text/xml; charset="utf-8" ------=_NextPart_01C9C745.DDF34BB0--