Zorina S. Galis, Ph.D. 

Lessner SM, Martinson DE and Galis ZS. Compensatory vascular remodeling during atherosclerotic lesion growth depends on matrix metalloproteinase-9 activity. Arterioscler Thromb Vasc Biol 24: 2123-2129, 2004.

Galis ZS. Vulnerable plaque: the devil is in the details. Circulation 110: 244-246, 2004.

Sung HJ, Meredith C, Johnson C and Galis ZS. The effect of scaffold degradation rate on three-dimensional cell growth and angiogenesis. Biomaterials 25: 5735-5742, 2004.

Lessner SM and Galis ZS. Matrix metalloproteinases and vascular endothelium-mononuclear cell close encounters. Trends Cardiovasc Med 14: 105-111, 2004.
 

Kim SH, Lessner SM, Sakurai Y and Galis ZS. Cyclophilin A as a novel biphasic mediator of endothelial activation and dysfunction. Am J Pathol 164: 1567-1574, 2004.
 

Pasterkamp G, Galis ZS and de Kleijn DP. Expansive arterial remodeling: location, location, location. Arterioscler Thromb Vasc Biol 24: 650-657, 2004.
 

Khatri JJ, Johnson C, Magid R, Lessner SM, Laude KM, Dikalov SI, Harrison DG, Sung HJ, Rong Y and Galis ZS. Vascular oxidant stress enhances progression and angiogenesis of experimental atheroma. Circulation 109: 520-525, 2004.
 

Johnson C, Sung HJ, Lessner SM, Fini ME and Galis ZS. Matrix metalloproteinase-9 is required for adequate angiogenic revascularization of ischemic tissues: potential role in capillary branching. Circ Res 94: 262-268, 2004.
 

Johnson C and Galis ZS. Quantitative assessment of collagen assembly by live cells. J Biomed Mater Res A 67: 775-784, 2003.
 

Naghavi M, Libby P, Falk E, Casscells SW, Litovsky S, Rumberger J, Badimon JJ, Stefanadis C, Moreno P, Pasterkamp G, Fayad Z, Stone PH, Waxman S, Raggi P, Madjid M, Zarrabi A, Burke A, Yuan C, Fitzgerald PJ, Siscovick DS, de Korte CL, Aikawa M, Airaksinen KE, Assmann G, Becker CR, Chesebro JH, Farb A, Galis ZS, Jackson C, Jang IK, Koenig W, Lodder RA, March K, Demirovic J, Navab M, Priori SG, Rekhter MD, Bahr R, Grundy SM, Mehran R, Colombo A, Boerwinkle E, Ballantyne C, Insull W, Jr., Schwartz RS, Vogel R, Serruys PW, Hansson GK, Faxon DP, Kaul S, Drexler H, Greenland P, Muller JE, Virmani R, Ridker PM, Zipes DP, Shah PK and Willerson JT. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part II. Circulation 108: 1772-1778, 2003.
 

Johnson C and Galis ZS. Matrix metalloproteinase-2 and -9 differentially regulate smooth muscle cell migration and cell-mediated collagen organization. Arterioscler Thromb Vasc Biol 24: 54-60, 2004.
 

Berglund JD and Galis ZS. Designer blood vessels and therapeutic revascularization. Br J Pharmacol 140: 627-636, 2003.
 

Naghavi M, Libby P, Falk E, Casscells SW, Litovsky S, Rumberger J, Badimon JJ, Stefanadis C, Moreno P, Pasterkamp G, Fayad Z, Stone PH, Waxman S, Raggi P, Madjid M, Zarrabi A, Burke A, Yuan C, Fitzgerald PJ, Siscovick DS, de Korte CL, Aikawa M, Juhani Airaksinen KE, Assmann G, Becker CR, Chesebro JH, Farb A, Galis ZS, Jackson C, Jang IK, Koenig W, Lodder RA, March K, Demirovic J, Navab M, Priori SG, Rekhter MD, Bahr R, Grundy SM, Mehran R, Colombo A, Boerwinkle E, Ballantyne C, Insull W, Jr., Schwartz RS, Vogel R, Serruys PW, Hansson GK, Faxon DP, Kaul S, Drexler H, Greenland P, Muller JE, Virmani R, Ridker PM, Zipes DP, Shah PK and Willerson JT. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I. Circulation 108: 1664-1672, 2003.
 

Seliktar D, Nerem RM and Galis ZS. Mechanical strain-stimulated remodeling of tissue-engineered blood vessel constructs. Tissue Eng 9: 657-666, 2003.
 

Magid R, Murphy TJ and Galis ZS. Expression of matrix metalloproteinase-9 in endothelial cells is differentially regulated by shear stress. Role of c-Myc. J Biol Chem 278: 32994-32999, 2003.
 

Burke AP, Virmani R, Galis Z, Haudenschild CC and Muller JE. 34th Bethesda Conference: Task force #2--What is the pathologic basis for new atherosclerosis imaging techniques? J Am Coll Cardiol 41: 1874-1886, 2003.
 

Magid R, Martinson D, Hwang J, Jo H and Galis ZS. Optimization of isolation and functional characterization of primary murine aortic endothelial cells. Endothelium 10: 103-109, 2003.
 

Asanuma K, Magid R, Johnson C, Nerem RM and Galis ZS. Uniaxial strain upregulates matrix-degrading enzymes produced by human vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 284: H1778-H1784, 2003.
 

Roman J and Galis ZS. Sarcoidosis: a mysterious tale of inflammation, tissue remodeling, and matrix metalloproteinases. Hum Pathol 33: 1155-1157, 2002.
 

Galis ZS, Johnson C, Godin D, Magid R, Shipley JM, Senior RM and Ivan E. Targeted disruption of the matrix metalloproteinase-9 gene impairs smooth muscle cell migration and geometrical arterial remodeling. Circ Res 91: 852-859, 2002.
 

Lessner SM, Prado HL, Waller EK and Galis ZS. Atherosclerotic lesions grow through recruitment and proliferation of circulating monocytes in a murine model. Am J Pathol 160: 2145-2155, 2002.
 

Ivan E, Khatri JJ, Johnson C, Magid R, Godin D, Nandi S, Lessner S and Galis ZS. Expansive arterial remodeling is associated with increased neointimal macrophage foam cell content: the murine model of macrophage-rich carotid artery lesions. Circulation 105: 2686-2691, 2002.
 

Galis ZS and Khatri JJ. Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad, and the ugly. Circ Res 90: 251-262, 2002.
 

Seliktar D, Nerem RM and Galis ZS. The role of matrix metalloproteinase-2 in the remodeling of cell-seeded vascular constructs subjected to cyclic strain. Ann Biomed Eng 29: 923-934, 2001.
 

Shah PK and Galis ZS. Matrix metalloproteinase hypothesis of plaque rupture: players keep piling up but questions remain. Circulation 104: 1878-1880, 2001.
 

Mavromatis K, Fukai T, Tate M, Chesler N, Ku DN and Galis ZS. Early effects of arterial hemodynamic conditions on human saphenous veins perfused ex vivo. Arterioscler Thromb Vasc Biol 20: 1889-1895, 2000.
 

Somers MJ, Mavromatis K, Galis ZS and Harrison DG. Vascular superoxide production and vasomotor function in hypertension induced by deoxycorticosterone acetate-salt. Circulation 101: 1722-1728, 2000.
 

Galis ZS. Atheroma morphology and mechanical strength: looks are important, after all--lose the fat. Circ Res 86: 1-3, 2000.
 

Godin D, Ivan E, Johnson C, Magid R and Galis ZS. Remodeling of carotid artery is associated with increased expression of matrix metalloproteinases in mouse blood flow cessation model. Circulation 102: 2861-2866, 2000.
 

Chesler NC, Ku DN and Galis ZS. Transmural pressure induces matrix-degrading activity in porcine arteries ex vivo. Am J Physiol 277: H2002-H2009, 1999.
 

Meng X, Mavromatis K and Galis ZS. Mechanical stretching of human saphenous vein grafts induces expression and activation of matrix-degrading enzymes associated with vascular tissue injury and repair. Exp Mol Pathol 66: 227-237, 1999.
 

Coker ML, Doscher MA, Thomas CV, Galis ZS and Spinale FG . Matrix metalloproteinase synthesis and expression in isolated LV myocyte preparations. Am J Physiol 277: H777-H787, 1999.
 

Rajavashisth TB, Liao JK, Galis ZS, Tripathi S, Laufs U, Tripathi J, Chai NN, Xu XP, Jovinge S, Shah PK and Libby P. Inflammatory cytokines and oxidized low density lipoproteins increase endothelial cell expression of membrane type 1-matrix metalloproteinase. J Biol Chem 274: 11924-11929, 1999.
 

Li Z, Froehlich J, Galis ZS and Lakatta EG. Increased expression of matrix metalloproteinase-2 in the thickened intima of aged rats. Hypertension 33: 116-123, 1999.
 

Galis ZS, Asanuma K, Godin D and Meng X. N-acetyl-cysteine decreases the matrix-degrading capacity of macrophage-derived foam cells: new target for antioxidant therapy? Circulation 97: 2445-2453, 1998.
 

Coker ML, Thomas CV, Clair MJ, Hendrick JW, Krombach RS, Galis ZS and Spinale FG. Myocardial matrix metalloproteinase activity and abundance with congestive heart failure. Am J Physiol 274: H1516-H1523, 1998.
 

Fukai T, Galis ZS, Meng XP, Parthasarathy S and Harrison DG. Vascular expression of extracellular superoxide dismutase in atherosclerosis. J Clin Invest 101: 2101-2111, 1998.
 

Wesley RB, Meng X, Godin D and Galis ZS. Extracellular matrix modulates macrophage functions characteristic to atheroma: collagen type I enhances acquisition of resident macrophage traits by human peripheral blood monocytes in vitro. Arterioscler Thromb Vasc Biol 18: 432-440, 1998.
 

Galis ZS, Kranzhofer R, Fenton JW and Libby P. Thrombin promotes activation of matrix metalloproteinase-2 produced by cultured vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 17: 483-489, 1997.
 

Laursen JB, Rajagopalan S, Galis Z, Tarpey M, Freeman BA and Harrison DG. Role of superoxide in angiotensin II-induced but not catecholamine-induced hypertension. Circulation 95: 588-593, 1997.
 

Rajagopalan S, Meng XP, Ramasamy S, Harrison DG and Galis ZS. Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability. J Clin Invest 98: 2572-2579, 1996.
 

Galis ZS, Sukhova GK and Libby P. Microscopic localization of active proteases by in situ zymography: detection of matrix metalloproteinase activity in vascular tissue. FASEB J 9: 974-980, 1995.
 

Galis ZS, Sukhova GK, Kranzhofer R, Clark S and Libby P. Macrophage foam cells from experimental atheroma constitutively produce matrix-degrading proteinases. Proc Natl Acad Sci U S A 92: 402-406, 1995.
 

Galis ZS, Muszynski M, Sukhova GK, Simon-Morrissey E and Libby P. Enhanced expression of vascular matrix metalloproteinases induced in vitro by cytokines and in regions of human atherosclerotic lesions. Ann N Y Acad Sci 748: 501-507, 1995.
 

Libby P and Galis ZS. Cytokines regulate genes involved in atherogenesis. Ann N Y Acad Sci 748: 158-168, 1995.
 

Libby P, Sukhova G, Lee RT and Galis ZS. Cytokines regulate vascular functions related to stability of the atherosclerotic plaque. J Cardiovasc Pharmacol 25 Suppl 2: S9-12, 1995.
 

Galis ZS, Sukhova GK, Lark MW and Libby P. Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques. J Clin Invest 94: 2493-2503, 1994.
 

Galis ZS, Muszynski M, Sukhova GK, Simon-Morrissey E, Unemori EN, Lark MW, Amento E and Libby P. Cytokine-stimulated human vascular smooth muscle cells synthesize a complement of enzymes required for extracellular matrix digestion. Circ Res 75: 181-189, 1994.
 

Galis ZS, Alavi MZ and Moore S. Co-localization of aortic apolipoprotein B and chondroitin sulfate in an injury model of atherosclerosis. Am J Pathol 142: 1432-1438, 1993.
 

Li Z, Alavi MZ, Wasty F, Galis Z and Moore S. Proteoglycan synthesis by the neointimal smooth muscle cells cultured from rabbit aortic explants following de-endothelialization. Pathobiology 61: 89-94, 1993.
 

Galis ZS, Alavi MZ and Moore S. Sulfated proteoglycans of rabbit aorta: selective extraction and alternative method for glycosaminoglycan moiety analysis. Anal Biochem 204: 390-397, 1992.
 

Alavi MZ, Wasty F, Li Z, Galis ZS, Ismail N and Moore S. Enhanced incorporation of [14C]glucosamine into glycosaminoglycans of aortic neointima of balloon-injured and cholesterol-fed rabbits in vitro. Atherosclerosis 95: 59-67, 1992.
 

Galis ZS, Ghitescu LD, Li Z, Alavi MZ and Moore S. Distribution of endogenous apoprotein B-containing lipoproteins in normal and injured aortas of normocholesterolemic rabbits. Lab Invest 66: 624-638, 1992.
 

Galis ZS, Alavi MZ and Moore S. In situ ultrastructural characterization of chondroitin sulfate proteoglycans in normal rabbit aorta. J Histochem Cytochem 40: 251-263, 1992.
 

Alavi MZ, Galis Z, Li ZH and Moore S. Dietary alterations of plasma lipoproteins influence their interactions with proteoglycan enriched extracts from neointima of normal and injured aorta of rabbit. Clin Invest Med 14: 419-431, 1991.
 

Ghitescu L, Galis Z and Bendayan M. Protein AG-gold complex: an alternative probe in immunocytochemistry. J Histochem Cytochem 39: 1057-1065, 1991.
 

Galis Z, Ghitescu L and Simionescu M. Fatty acids binding to albumin increases its uptake and transcytosis by the lung capillary endothelium. Eur J Cell Biol 47: 358-365, 1988.
 

Ghitescu L, Galis Z, Simionescu M and Simionescu N. Differentiated uptake and transcytosis of albumin in successive vascular segments. J Submicrosc Cytol Pathol 20: 657-669, 1988.
 

Tasca SI and Galis Z. Ultrastructural autoradiographic localization of exogenous arachidonic acid in cultured endothelial and smooth muscle cells. Prostaglandins Leukot Essent Fatty Acids 33: 165-171, 1988.